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KMID : 1007020100080020160
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Korean Soceity of Osteroporosis
2010 Volume.8 No. 2 p.160 ~ p.170
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Changes in Microstructure of Proximal Femoral Trabecular Bone
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Son Kwang-Hyun
Won Ye-Yeon
Kim Sang-Hwan
Park Jin
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Abstract
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Objectives: We hypothesize that the age-related changes in trabecular bone microstructure appear to be varied from specific anatomic sub-regions of the proximal femur followed by non-uniform bone loss. The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging.
Methods: A total of 162 trabecular bone cores from six regions of 27 femora of male cadaver donors were scanned using micro-computed tomography (micro-CT). The following microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular number (Tb. N), thickness (Tb.Th) and separation (Tb.Sp), structure model index (SMI), and degree of anisotropy (DOA).
Results: Age-related changes in trabecular microstructure varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference in BV/TV, Tb.Th, Tb.Sp, Tb. N and DOA between superior and inferior neck, as well as a significant difference in BV/TV, Tb.Sp, Tb. N, SMI and DOA between superior and inferior trochanter.
Conclusion: Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this cadaveric population.
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KEYWORD
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Proximal femur, Trabecular bone
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